Ir Genes: Past, Present, and Future Cover

Ir Genes: Past, Present, and Future

ISBN/ASIN: 9781461256359,9781461256335 | 1983 | English | pdf | 622/573 pages | 16.8 Mb
Publisher: Humana Press | Author: Chella S. David, William P. Lafuse (auth.), Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Benjamin D. Schwartz, Donald C. Shreffler (eds.) | Edition: 1

The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

Ir Genes: Past, Present, and Future

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