Pathogenesis and Treatment of Diabetes Mellitus
ISBN/ASIN: 9789401084116,9789400943018 | 1986 | English | pdf | 188/181 pages | 6.26 Mb
Publisher: Springer Netherlands | Author: J. K. Radder (auth.), J. K. Radder, H. H. P. J. Lemkes, H. M. J. Krans (eds.) | Edition: 1
In this book on diabetes mellitus both the pathogenesis and treat ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out break of the disease, the destructive process has already been active for years.