Non-Myeloablative Allogeneic Transplantation
ISBN/ASIN: 9781461353041,9781461509196 | 2002 | English | pdf | 216/218 pages | 4.67 Mb
Publisher: Springer US | Author: Januario E. Castro, Edward D. Ball (auth.), Asad Bashey M.D., Ph.D., Edward D. Ball M.D. (eds.) | Edition: 1
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.