Phosphoinositide 3-kinase in Health and Disease  Volume 1 Cover

Phosphoinositide 3-kinase in Health and Disease: Volume 1

ISBN/ASIN: 9783642136627,9783642136634 | 2011 | English | pdf | 310/310 pages | 4.05 Mb
Publisher: Springer-Verlag Berlin Heidelberg | Author: Tina L. Yuan, Lewis C. Cantley (auth.), Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt (eds.) | Edition: 1

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

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